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Pentosan P.S. is a disease-modifying osteoarthritis drug (DMOAD) used in equine medicine.
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It helps protect and repair joint cartilage, improve synovial fluid quality, and reduce inflammation associated with degenerative joint disease.
Composition (Active Ingredient)
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Pentosan Polysulfate Sodium (250 mg/mL)
Pharmacological Action
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Stimulates cartilage matrix synthesis (glycosaminoglycans & proteoglycans).
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Enhances synovial fluid viscosity for smoother joint function.
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Improves blood supply to subchondral bone and joint tissues.
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Provides anti-inflammatory activity by reducing harmful enzymes and mediators in joints.
Indications
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Horses with degenerative joint disease (DJD) / osteoarthritis.
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Management of joint pain and stiffness in performance horses.
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Recovery support after joint injury or strenuous exercise.
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Long-term joint health maintenance in aging horses.
Dosage & Administration
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3 mg/kg bodyweight (commonly 6 mL for a 500 kg horse).
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Intramuscular (IM) injection once weekly for 4 weeks.
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Maintenance dosing may be repeated every 3–6 months as needed.
Benefits
✔ Slows progression of joint degeneration
✔ Stimulates natural cartilage repair mechanisms
✔ Reduces joint pain and inflammation
✔ Improves mobility, flexibility, and performance
✔ Long-term joint protective therapy
Storage
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Store below 25°C, protected from light.
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Keep vial sealed and sterile until use.