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ACTH Gel (Adrenocorticotropic Hormone) is a sustained-release injectable preparation.
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Supplied in 10 mL multiple-dose sterile vials.
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Manufactured by Equimed USA and labeled “Export Only”.
Mechanism of Action
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Stimulates the adrenal cortex to secrete cortisol and corticosteroids.
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Cortisol regulates metabolism, inflammation, and stress responses.
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The gel formulation prolongs release, ensuring extended activity.
Veterinary Applications
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Diagnostic Use:
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Widely used in the ACTH stimulation test to evaluate adrenal gland function (e.g., PPID/Cushing’s disease in horses, adrenal insufficiency).
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Therapeutic Use (under veterinary control):
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Modulation of certain immune-mediated and inflammatory conditions.
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Rarely considered for performance horses due to strict anti-doping bans.
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Administration & Dosage
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Routes: Intramuscular (IM) or Subcutaneous (SC) injection.
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Dose: Depends on use (diagnostic vs therapeutic).
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Always requires veterinary supervision.
Benefits
✔ Provides a reliable stimulation test for diagnosing adrenal disorders.
✔ Long-acting formulation ensures sustained cortisol release.
✔ Useful in evaluating PPID (Cushing’s disease) in horses.
✔ May help in managing inflammatory conditions under specific veterinary protocols.
✔ Multiple-dose vial offers cost-effective diagnostic use.
Precautions
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Risk of excess cortisol production → possible laminitis, immunosuppression, or adrenal suppression.
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Not for casual or unsupervised use.
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Strictly prohibited in competition:
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FEI – Controlled & Banned Substance.
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HISA (USA) – Zero tolerance.
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Dubai Racing Authority – Requires long withdrawal period.
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