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Adenosine is a purine nucleoside naturally present in the body, playing key roles in cellular energy transfer (ATP/ADP/AMP) and neuromodulation.
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Supplied as a sterile injectable solution in a 50 mL multiple-dose vial by Equimed USA.
Mechanism of Action
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Acts on adenosine receptors (A1, A2A, A2B, A3) to regulate cardiovascular, neurological, and muscular functions.
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Causes transient slowing of AV nodal conduction → useful in managing arrhythmias.
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Promotes vasodilation → enhances blood flow and tissue oxygenation.
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Plays a role in anti-inflammatory and cytoprotective pathways.
Veterinary Applications
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Cardiac Uses:
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Management of certain tachyarrhythmias (especially supraventricular tachycardia).
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Exercise Physiology / Performance Horses:
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Studied for its role in muscle blood flow, recovery, and fatigue reduction.
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Research & Specialized Therapies:
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Sometimes investigated for its anti-inflammatory and metabolic effects in equine medicine.
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Administration & Dosage
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Administered intravenously (IV) for rapid cardiac effects.
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Dosing varies depending on species, indication, and clinical setting.
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Must be given under strict veterinary supervision due to strong cardiovascular effects.
Benefits
✔ Effective in diagnosing and managing certain arrhythmias.
✔ Promotes vasodilation and improves muscle oxygenation.
✔ May assist in reducing muscle fatigue and stress during intensive exercise.
✔ Provides short-acting but powerful cardiovascular regulation, allowing controlled use in diagnostics and treatment.
Precautions
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Can cause bradycardia, hypotension, or transient asystole if misused.
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Short half-life → effects are brief but immediate.
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Must be used with emergency monitoring.
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Regulatory Status:
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Banned in competition (FEI, HISA, Dubai Racing Authority) due to potential performance enhancement and cardiovascular effects.
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Withdrawal times must be carefully observed.
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